After a large-scale radiological event,
there will be a major need to assess,
within a few days, the radiation doses received by tens or
hundreds of thousands of individuals.
Our Center is a research consortium
to develop practical, high throughput, minimally-invasive radiation dose
assessment devices and techniques to meet this need.
initial studies focused exclusively on external whole-body
photon irradiation. To build on these studies, our current
focus is to assess the significance of the variety of other
radiation scenarios that are likely to occur, in particular
the effects of partial-body exposure, internal emitters,
low dose rate, and neutron exposure.
dose: Towards individual radiosensitivity"
that we have developed high-throughput systems for using
various biomarkers for biodosimetry, we also are in a unique
position to probe the application of these biomarkers for
predicting inter-individual sensitivity to acute radiation
syndromes. This will enable us to examine correlations between
our high-throughput biomarkers and individual acute radiation
sensitivity, and it will enable us to probe the associated
mechanisms of individual acute radiation sensitivity.
This Consortium represents
a multidisciplinary balance between radiation biologists,
radiation physicists, radiation chemists, mechanical engineers,
software engineers, product development experts, commercial
companies in the field, and end users. The three areas we
have identified as having the highest potential for high-throughput
biodosimetry are cytogenetics, functional
genomics, and metabolomics.
Each area has its own project in the Current Directions
and is supported by Irradiation,
Fabrication, and Informatics
and Biostatistics cores.
1) Developed high-throughput systems
for using various biomarkers for biodoismetry
2) Demonstrated, for the first
time, the ability of a single gene set to predict radiation dose
over a significant period post-irradiation without
individual pre-exposure controls
the potential for a urine-based metabolomics biodosimetry
system, with signals increasing in a dose-response manner, and
with a signal lifetime of at least several days.
Pilot Project Research Program:
The Consortium supports several Pilot Projects
each year that have the potential to increase the capabilities for high-throughput
biodosimetry, but may not have the prior development needed for a full
stand alone grant. Previously funded Pilot Projects are reported
on the Pilot Projects page.
for 2014 Pilot Project Proposals. (Deadline - March 31, 2014.)
- We are seeking
applications for pilot project funding relating to high-throughput minimally-invasive radiation biodosimetry.
- The projects
will be part of a joint NIH-funded program involving Columbia University,
Georgetown University, Lovelace Respiratory Research Institute, New York University,
Translational Genomics Research Institute,
and University of Bern. Details of the program can be found
- We currently
support biodosimetry projects using cytogenetic, gene expression,
and metabolomic endpoints, and we are looking for biodosimetry-oriented
pilot projects which will either complement these areas, or open
up new research avenues. The projects can be biologically- or physically-based,
but must ultimately be directed towards practical high-throughput
radiation biodosimetry or dosimetry, after external photon or neutron
exposure, or internal radiation exposure. Innovative proposals for
testing new concepts are encouraged.
- Each pilot
project will be of limited duration (up to one year) and of a limited
budget (up to $75,000 direct costs/year/project). The maximum individual award is $100K per year total costs.
- The application
due date is March 31, 2014, with a projected start date of August
- Full application
details are given on the next page. Please address technical inquiries
to the PI, David J. Brenner at firstname.lastname@example.org.
Administrative questions and applications should be addressed to
Erica Pena at email@example.com, telephone: 212-305-5660.
Training Courses and
We have hosted several courses and
workshops on Radiation Biodosimetry. The lectures from these
courses are available as Podcasts for downloading.
Extended abstracts for
Individual Radiation Sensitivity: Current and Evolving Technologies"
hosted at Columbia University, March 17-18, 2008
are available in Radiation Research
170, 666-675, 2008
The six institutions involved
in the research consortium are:
New York, NY
University, Washington, D.C.
Lovelace Respiratory Research Institute,
New York University School of
Medicine, New York, NY
Genomics Research Institute, Phoenix,
Bern, Bern, Switzerland
Research is funded
by the National
Institute of Allergy and Infectious Diseases (NIAID), part of the National
Institute of Health (NIH)