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Center for High-Throughput Minimally-Invasive Radiation Biodosimetry

Overview

After a large-scale radiological event, there will be a major need to assess, within a few days,the radiation doses received by tens or hundreds of thousands of individuals.
Our Center is a research consortium to develop practical, high throughput, minimally-invasive radiation dose assessment devices and techniques to meet this need. This Consortium represents a multidisciplinary balance between radiation biologists, radiation physicists, radiation chemists, mechanical engineers, software engineers, product development experts, commercial companies in the field, and end users. The three areas we have identified as having the highest potential for high-throughput biodosimetry are:

Automated cytogenetics

Transcriptomics

Metabolomics

The structure of our CMCR is described here.

Our work focuses on three main directions:

Beyond Simple Exposures

Historically, biodosimetry studies have focused on external whole-body photon irradiation. To build on these studies, our current focus is to assess the significance of a variety of other radiation scenarios that are likely to occur, in particular the effects of internal emitters, different dose rates, and neutron exposure.

Beyond dose

In that we have developed high-throughput systems for using various biomarkers for biodosimetry, we also are in a unique position to probe the application of these biomarkers for predicting inter-individual sensitivity to acute radiation syndromes. This will enable us to examine correlations between our high-throughput biomarkers and individual late radiation sensitivity, specifically the severity of pneumonitis, and it will enable us to probe the associated mechanisms of individual raidation pneumonitis reponse and recovery

Technology Development

Our third theme is technology development. We build on the fact that, in contrast to when the CMCR program was initiated, commercial high-throughput technologies for cell handling, gene expression, and metabolomics are now increasingly available in university, industry, and in clinical testing laboratories.

 

 Research is funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institute of Health (NIH)

Links

CRR

RARAF

Columbia University

Georgetown

NIAID

 



tel: (212) 305-5660
fax: (212) 305-3220
Center for High-Throughput Minimally-Invasive Radiation Biodosimetry