Center for High-Throughput Minimally-Invasive Radiation Biodosimetry
After a large-scale radiological event, there will be a major need to assess, within a few days,the radiation doses received by tens or hundreds of thousands of individuals.
Our Center is a research consortium to develop practical, high throughput, minimally-invasive radiation dose assessment devices and techniques to meet this need. This Consortium represents a multidisciplinary balance between radiation biologists, radiation physicists, radiation chemists, mechanical engineers, software engineers, product development experts, commercial companies in the field, and end users. The three areas we have identified as having the highest potential for high-throughput biodosimetry are:
The structure of our CMCR is described here.
Our work focuses on three main directions:
Beyond Simple Exposures
Historically, biodosimetry studies have focused on external whole-body photon irradiation. To build on these studies, our current focus is to assess the significance of a variety of other radiation scenarios that are likely to occur, in particular the effects of internal emitters, different dose rates, and neutron exposure.
In that we have developed high-throughput systems
for using various biomarkers for biodosimetry, we also are
in a unique position to probe the application of these biomarkers
for predicting inter-individual sensitivity to acute radiation
syndromes. This will enable us to examine correlations between
our high-throughput biomarkers and individual late radiation
sensitivity, specifically the severity of pneumonitis, and
it will enable us to probe the associated mechanisms of individual
raidation pneumonitis reponse and recovery
Our third theme is technology development. We
build on the fact that, in contrast to when the CMCR program
was initiated, commercial high-throughput technologies for
cell handling, gene expression, and metabolomics are now increasingly
available in university, industry, and in clinical testing
Research is funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institute of Health (NIH)