Salivary metabolomics have been
utilized before to discriminate individuals with oral cancer,
periodontal disease, breast cancer, and pancreatic cancer. With
the oral mucosa and salivary glands being exceptionally radiosensitive,
we investigated the metabolic profiles of mouse saliva. Polar
analysis showed a dose response present in many metabolites. As
this is the first study to show salivary responses with metabolomics,
we will explore this biofluid further for its potential in radiation
biodosimetry. The results of the pilot project are currently in
press in Radiation Research.
Simple depiction of the experimental plan.
Pathway enrichment reveals key metabolic pathways
that are affected following exposure
to 8 Gy of gamma-rays (LD50/30 for C57BL/6 male mice).
Laiakis EC, Strawn SJ, Brenner DJ, Fornace Jr
AJ. Assessment of saliva as a potential biofluid for
biodosimetry: a pilot metabolomics study in mice.
In Press at Radiation Research.